Current Practice of Intravenous and Subcutaneous Chlorpromazine for Sleep Disturbance in a Palliative Care Unit, with a Focus on Concomitant Use of Midazolam: A Retrospective Descriptive Study

January 1, 2026Palliative Care ResearchOpen Access

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Key Points

The study investigates the use of chlorpromazine for sleep disturbances in a palliative care setting, focusing on its combined use with midazolam.
Analyzed records of 126 patients receiving chlorpromazine.
Evaluated sleep scores and consciousness levels for 98 patients on chlorpromazine for over three days.
Assessed the prevalence of midazolam co-use and adverse effects.
Midazolam was co-administered in 78.5% of cases.
Adverse effects of chlorpromazine were noted in 9.5% of cases, primarily sedation and extrapyramidal symptoms.
Sleep scores showed improvement trends, but some patients experienced decreased daytime alertness.

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Retrospective analysis examines chlorpromazine's effects on sleep disturbance in patients, highlighting safety issues.

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Cho et al. (2026) studied this question.

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