What question did this study set out to answer?

To explore how inhibiting metabolic pathways influences the occurrence of adverse drug reactions (ADRs).

February 23, 2026British Journal of Clinical Pharmacology0 citationsOpen Access

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

JBJudith BerresRWTH Aachen University JWJustyna WozniakUniversitätsklinikum Aachen HFHannah FölschRWTH Aachen University

Key Points

To explore how inhibiting metabolic pathways influences the occurrence of adverse drug reactions (ADRs).
Applied a backward selection approach to identify inhibited pathways.
Analyzed data correlating metabolism-inhibiting drugs with ADR occurrence.
Proposed further validation in an additional dataset.
High burden of pathway inhibition is linked to increased ADR occurrence.
Identified key pathways that contribute to ADRs in the analyzed dataset.

Abstract

Our approach identifies plausible inhibited pathways, raising awareness that a high burden of pathway inhibition can contribute to the occurrence of ADRs. Further validation in a second dataset is necessary.

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