What question did this study set out to answer?

This review aims to clarify the relationship between hepatitis E virus infection and inflammatory bowel disease (IBD).

February 23, 2026Journal of Viral HepatitisOpen Access

Hepatitis E Infection in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta‐Analysis

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Systematic review assesses hepatitis E infection's impact in inflammatory bowel disease, suggesting testing for effective diagnosis.

This review aims to clarify the relationship between hepatitis E virus infection and inflammatory bowel disease (IBD).
Conducted a systematic review and meta-analysis using literature from PubMed/MEDLINE and Google Scholar.
Included studies focused on HEV infection in ulcerative colitis or Crohn's disease patients.
Quality of studies assessed with the Joanna Briggs Institute Checklist.
Pooled prevalence of anti-HEV IgG antibodies in IBD patients was 13.5% with notable heterogeneity.
Anti-HEV IgM positivity was 1.9% and HEV-RNA positivity was 0.03%.
Prevalence rates for IBD patients were similar to those in the general population.

Kogias et al. (2026) studied this question.

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