Why the study?
Given the complex relationship between CVD and CKD, CVD-related markers may serve as CKD biomarkers.
Are elevated levels of myocardial stress markers (MR-proADM, MR-proANP, NT-proBNP) associated with reduced kidney function and higher prevalence/incidence of chronic kidney disease in the general population?
Population
Up to 61,830 participants in cross-sectional analyses and 4205 individuals in longitudinal analyses
Comparison
Levels of MR-proADM, MR-proANP, and NT-proBNP categorized into four groups
Design
Cross-sectional and longitudinal analyses
Follow-up
10-year
Key result
Higher levels of NT-proBNP were associated with a 2.35 ml/min/1.73m2 lower eGFR (per 1 SD increase) and a 1.81-fold higher odds of prevalent CKD cross-sectionally, and with a 1.37 ml/min/1.73m2 faster 10-year eGFR decline and 1.39-fold higher risk of incident CKD longitudinally in a European general adult population.
Authors
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NT-proBNP may flag higher CKD risk in general adults; extends prior cardio-renal associations longitudinally but leaves causality open.
Observational (n=61,830)
Yes
Are elevated levels of myocardial stress markers (MR-proADM, MR-proANP, NT-proBNP) associated with reduced kidney function and higher prevalence/incidence of chronic kidney disease in the general population?
Effect estimate: Cross-sectional: For each 1 SD increase in log-transformed NT-proBNP, eGFRcr-cys decreased by 2.35 ml/min/1.73m2; Odds ratio (OR) for prevalent CKDcr-cys was 1.81 (95% CI 1.72–1.90); Highest NT-proBNP group (≥300 pg/ml) had OR 5.72 (95% CI 4.82–6.78) vs lowest group (<48 pg/ml). Longitudinal: For each 1 SD increase in log-transformed NT-proBNP, 10-year decline in eGFRcr-cys was –1.37 ml/min/1.73m2 (95% CI –1.77 to –0.98); Hazard ratio (HR) for incident CKDcr-cys was 1.39 (95% CI 1.20–1.62); Highest NT-proBNP group had HR 4.40 (95% CI 2.63–7.36) vs lowest group. (95% CI As stated above.)
p-value: p=All associations statistically significant with p<0.05, many p<0.001
Higher levels of myocardial stress markers (MR-proADM, MR-proANP, and NT-proBNP) are significantly associated with lower kidney function and higher prevalence and incidence of chronic kidney disease in the general population.
Lin et al. (2026) conducted an observational in General adult population from Europe with variable cardiovascular disease and diabetes status, assessed for kidney function and chronic kidney disease (n=61,830). Higher levels of myocardial stress markers (NT-proBNP, MR-proANP, MR-proADM) vs. Lower levels of these markers (group 1) was evaluated on Kidney function measured by estimated glomerular filtration rate (eGFRcr-cys) and prevalence/incidence of chronic kidney disease (CKDcr-cys defined as eGFR < 60 ml/min/1.73m2) (Cross-sectional: For each 1 SD increase in log-transformed NT-proBNP, eGFRcr-cys decreased by 2.35 ml/min/1.73m2; Odds ratio (OR) for prevalent CKDcr-cys was 1.81 (95% CI 1.72–1.90); Highest NT-proBNP group (≥300 pg/ml) had OR 5.72 (95% CI 4.82–6.78) vs lowest group (<48 pg/ml). Longitudinal: For each 1 SD increase in log-transformed NT-proBNP, 10-year decline in eGFRcr-cys was –1.37 ml/min/1.73m2 (95% CI –1.77 to –0.98); Hazard ratio (HR) for incident CKDcr-cys was 1.39 (95% CI 1.20–1.62); Highest NT-proBNP group had HR 4.40 (95% CI 2.63–7.36) vs lowest group., 95% CI As stated above., p=All associations statistically significant with p<0.05, many p<0.001). Higher levels of NT-proBNP were associated with a 2.35 ml/min/1.73m2 lower eGFR (per 1 SD increase) and a 1.81-fold higher odds of prevalent CKD cross-sectionally, and with a 1.37 ml/min/1.73m2 faster 10-year eGFR decline and 1.39-fold higher risk of incident CKD longitudinally in a European general adult population.