ABSTRACT Background Sinonasal adenoid cystic carcinoma (AdCC) has a limited prognosis. This study assesses its incidence and prognostic factors in The Netherlands, focusing on histopathological features. Methods Adult patients diagnosed during 2008–2022 were retrieved through the Netherlands Cancer Registry and the Dutch Pathology Registry. Prognostic factors were assessed using survival analyses. Results Ninety‐nine patients were included. The yearly incidence fluctuated between 3 and 14 cases (RESR: 0.02–0.08 per 100 000 person‐years). Five‐year overall, relative, and progression‐free survival were 51%, 55%, and 62%. Multivariable analysis showed solid growth and non‐surgical treatment to be independently associated with poorer overall and relative survival after correction for age, tumor location, and T stage. Non‐surgical treatment was mainly used for advanced disease and was mainly palliative when intent was recorded. No significant survival differences were found among the different T stages. Sex, perineural invasion, and (lympho)vascular invasion did not impact survival. Conclusion The presence of any solid growth can be used as a prognostic indicator. The absence of survival differences between T stages may indicate that sinonasal AdCC's behavior does not fully align with the standard TNM classification, with factors such as solid growth potentially being more prognostically relevant.
Velde et al. (Sun,) studied this question.
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