What does this research mean for the field?

In children with newly diagnosed type 1 diabetes mellitus, 18% have raised thyroid peroxidase antibodies, and 14% develop hypothyroidism, while adrenal autoantibodies and dysfunction are infrequent. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The aim was to determine the prevalence of thyroid and adrenal autoimmunity in children diagnosed with type 1 diabetes mellitus.

February 25, 2026Journal of Pediatric Endocrinology and DiabetesOpen Access

Thyroid and adrenal autoimmunity in children with newly diagnosed type 1 diabetes mellitus

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Authors

ODOrla DempseyRoyal Hospital for Children JPJonathan PinskerRoyal Hospital for Children ALAngela Lucas-HeraldRoyal Hospital for Children

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Implication

A retrospective review identifies thyroid and adrenal autoimmunity in children with type 1 diabetes, indicating significant prevalence of thyroid issues.

Key Points

The aim was to determine the prevalence of thyroid and adrenal autoimmunity in children diagnosed with type 1 diabetes mellitus.
Conducted a retrospective case review of children with newly diagnosed T1DM
Analyzed antibody status and function data from diagnosis until May 2024
Reviewed medical records at the Royal Hospital for Children, Glasgow
Among 504 children diagnosed with T1DM, 18% had raised TPO antibodies
14% developed hypothyroidism, most with detectable antibodies at T1DM diagnosis
No children with positive adrenal autoantibodies developed adrenal dysfunction after a median follow-up of 4 years

Cite This Study

Dempsey et al. (2026) studied this question.

synapsesocial.com/papers/699e90eff5123be5ed04e1b8 https://doi.org/10.25259/jped_78_2025

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Implication

A retrospective review identifies thyroid and adrenal autoimmunity in children with type 1 diabetes, indicating significant prevalence of thyroid issues.

Thyroid and adrenal autoimmunity in children with newly diagnosed type 1 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

Thyroid and adrenal autoimmunity in children with newly diagnosed type 1 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

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