A systematic review finds hypertonic saline and mannitol equally reduce intracranial pressure in pediatric traumatic brain injury, suggesting potential benefits of hypertonic saline.
In pediatric TBI, hypertonic saline and mannitol provide comparable efficacy for ICP reduction and mortality, with HTS demonstrating rapid ICP lowering and manageable safety signals. While HTS is generally well tolerated, further high-quality multicenter RCTs with standardized protocols and long-term outcomes are needed to clarify its clinical advantages over mannitol.
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Alsabri et al. (2026) studied this question.
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