Demonstrates lamotrigine's effect on quetiapine levels in patients with depression, suggesting genotype variations influence outcomes.
The present study provides evidence that low-dose lamotrigine co-administration decreases plasma quetiapine concentrations in Japanese patients with depression and that the magnitude of this effect differs between genotypes of the UGT2B7 -161C>T polymorphism.
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Suzuki et al. (2026) studied this question.
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