Systematic review evaluates modafinil's effects on post-stroke fatigue, suggesting cautious use in practice.
Current evidence does not support modafinil as a routine treatment for PSF. Its effect on mental fatigue is of very low certainty, limiting the strength of this finding. Clinicians should interpret these findings cautiously, and use modafinil only on a case-by-case basis. Larger, high-quality trials with standardized fatigue measures are needed to identify responders and clarify its clinical role.
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Petry et al. (2026) studied this question.
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