Key result
Modafinil (400 mg/day) was not superior to placebo in alleviating fatigue or improving quality of life in patients with post-polio syndrome.
Why the study?
Does modafinil improve fatigue in patients with post-polio syndrome?
RCT (n=36)
randomized crossover
Does modafinil improve fatigue in patients with post-polio syndrome?
Modafinil at 400 mg/day does not significantly improve fatigue or quality of life in patients with post-polio syndrome compared to placebo.
No takes yet. Share an insight, caveat, or question.
Does not support modafinil for post-polio fatigue; confirms lack of benefit in this RCT and shifts research focus to alternatives.
Vasconcelos et al. (2007) conducted an RCT in post-polio syndrome (n=36). Modafinil vs. Placebo was evaluated on Fatigue assessed using the Fatigue Severity Scale. Modafinil (400 mg/day) was not superior to placebo in alleviating fatigue or improving quality of life in patients with post-polio syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: