Total flavonoids of Abelmoschus manihot (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis.

Key Points

• To investigate how total flavonoids from Abelmoschus manihot affect early renal injury in diabetic kidney disease through the LINC00665/miR-379-5p axis.
• Analyzed the effects of total flavonoids on early renal injury in a diabetic kidney disease model.
• Examined changes in LINC00665 and miR-379-5p expression levels.
• Utilized relevant biochemical assays to assess renal function.
• Total flavonoids successfully suppressed LINC00665 expression.
• Increased miR-379-5p activity was observed following treatment with total flavonoids.
• Therapeutic effects were noted in early renal injury markers.