The study demonstrates flavonoids modulate the linc00665/mir-379-5p axis to reduce renal injury in diabetic kidney disease, indicating a potential therapeutic strategy.
Conclusions: The LINC00665/miR-379-5p axis contributes to DKD pathogenesis. TFA exerts therapeutic effects against early renal injury in DKD by suppressing LINC00665 and consequently upregulating miR-379-5p activity.
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Li et al. (2026) studied this question.
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