Demonstrates how MSC-conditioned media affects leukemia growth in bone marrow, suggesting a novel therapy.
Summarizing, the leukemic blasts and AML-MSC in the BM microenvironment interact differentially in cell-cell contact compared to only soluble factors. Further, our study has provided innovative leads that PD-MSC-CM effectively abrogates leukemia tumor growth, enhances chemosensitivity and can be developed further as an immunomodulatory novel "off-the-shelf" therapeutic agent for leukemia.
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Nagare et al. (2026) studied this question.
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