Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025International Journal of Molecular SciencesOpen Access

Impact of Acute Myeloid Leukemia Cells on the Metabolic Function of Bone Marrow Mesenchymal Stem Cells

View Full Paper
Ask AI
Bookmark
Share

Authors

HAHelal Mohammed Mohammed AhmedPPPradeep Kumar PatnanaYAYahya Al-Matary

Discussion

Loading...

Member takes

Overview

Research demonstrates AML cells alter metabolic function of bone marrow mesenchymal stem cells, suggesting new therapeutic strategies.

Key Points

  • AML cells significantly reduce the metabolic capacity of bone marrow mesenchymal stem cells.
  • Gene Set Enrichment Analysis reveals downregulation of oxidative phosphorylation and glycolysis in AML-MSCs.
  • Coculture with AML cells consistently triggers metabolic shifts in both wild-type and healthy donor MSCs.
  • Findings point to metabolic vulnerabilities that may enable the development of targeted therapies for AML.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc9563f5https://doi.org/10.3390/ijms26178301
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells2008 · 608 citations
  2. 2Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet2009 · 3,421 citations
  3. 3Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular Mechanisms2017 · 88 citations