The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

An Liyuan; Yu Hirata; Tomoya Inoue; Kenji Sugawara; Wataru Ogawa

doi:10.1111/jdi.70270

February 22, 2026Journal of Diabetes InvestigationOpen Access

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

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Key Points

This research aims to examine how CXCL10 contributes to muscle inflammation and atrophy caused by a high-fat diet.
Evaluated the effects of CXCL10 on muscle tissue in high-fat diet models
Measured inflammation and proteolysis in skeletal muscle
Assessed the impact of CXCL10 neutralization on muscle loss
CXCL10 promotes inflammation leading to increased muscle atrophy
Neutralizing CXCL10 significantly reduces muscle loss
Findings suggest CXCL10 as a potential target for preserving muscle mass under metabolic stress

Implication

Demonstrates that CXCL10 promotes muscle atrophy in those on a high-fat diet, suggesting new treatments to protect muscle mass.

Abstract

CXCL10 mediates HFD-induced skeletal muscle atrophy by promoting inflammation and proteolysis. CXCL10 neutralization mitigates such muscle loss and may represent a novel therapeutic strategy to preserve skeletal muscle mass under metabolic stress.

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Cite This Study

Liyuan et al. (2026) studied this question.

synapsesocial.com/papers/699e9143f5123be5ed04ea66 https://doi.org/10.1111/jdi.70270

View Full Paper

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The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Key Points

Implication

Abstract

Discussion

Cite This Study

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Key Points

Implication

Abstract

Discussion

Cite This Study

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