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February 25, 2026Biology of Sex DifferencesOpen Access

Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice

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Authors

YZYutian ZhaoRLRuoshui LiuJNJonathan P. Ng

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Overview

Research reveals estradiol induces distinct gene regulation in adipose cells, suggesting implications for obesity in different sexes.

Key Points

  • This study aims to investigate the sex-specific effects of estradiol on gene regulation in adipose tissue of obese gonadectomized mice.
  • Measured adiposity in gonadectomized XX and XY mice
  • Used single-cell RNA sequencing to analyze gene expression
  • Conducted differential expression analysis and pathway enrichment
  • Modeled intracellular and intercellular networks
  • Analyzed human disease relevance of identified genes
  • E2 caused greater fat reduction in XX mice compared to XY mice
  • XX adipose stem and progenitor cells showed a stronger transcriptomic response to E2
  • E2 suppression of extracellular matrix genes was more pronounced in XY preadipocytes
  • Macrophages showed decreased lipid-associated proportions and altered immune genes in response to E2
  • Stronger communication between macrophages and ASPCs was observed in XX mice

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/699e9143f5123be5ed04eb09https://doi.org/10.1186/s13293-026-00859-z
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