Key result
Estrogens protect against metabolic disease by promoting subcutaneous fat storage and modulating lipolysis.
Why the study?
Sex differences in regulation of adipose tissue and their impact on metabolic disease resistance require comprehensive review.
This review highlights that estrogen-driven accumulation of subcutaneous adipose tissue in women confers a protective metabolic profile compared to visceral fat.
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May guide sex-specific metabolic risk assessment; leaves open prospective validation and therapeutic targeting.
Sulaieva et al. (2017) conducted a review in Adipose tissue regulation and metabolic diseases. Sex differences and estrogens vs. Males / low estrogen states was evaluated. Estrogens exert a pleiotropic protective effect by promoting subcutaneous fat accumulation and modulating lipolysis, determining female resistance to metabolic diseases.
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