What question did this study set out to answer?

To investigate the role of lncRNA H19 in STAT3-dependent fibroblast and keratinocyte activation in systemic sclerosis skin.

February 25, 20260 citations

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Long Non-Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin.

BCBegoña Caballero-RuizUniversity of Leeds CWChristopher W. WassonUniversity of Leeds RRR. RossUniversity of Leeds

Key Points

To investigate the role of lncRNA H19 in STAT3-dependent fibroblast and keratinocyte activation in systemic sclerosis skin.
Analyzed the expressions of lncRNA H19 in skin samples from systemic sclerosis cases.
Examined the effects of lncRNA H19 on fibroblast and keratinocyte activation through specific assays.
Used molecular techniques to assess STAT3 activation in these cells.
H19 expression was significantly elevated in systemic sclerosis skin samples.
lncRNA H19 facilitated STAT3 activation in both fibroblasts and keratinocytes.
Targeting lncRNA H19 may reduce fibrotic changes in skin associated with systemic sclerosis.

Abstract

This study shows that lncRNA H19 is a key mediator of STAT3 induced changes in fibrotic activation of fibroblast and keratinocytes in SSc skin and could be considered a promising therapeutic target in tissue fibrosis.

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Long Non-Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin.

Key Points

Abstract

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