Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 25, 2026ACS Applied Materials & Interfaces

Enhancing Mucus Penetration and Intestinal Epithelial Transport of Diacylglycerol Nanoparticles by Surface-Modification

View Full Paper
Ask AI
Bookmark
Share

Authors

DCDechu ChenMalaysian Palm Oil BoardCCCanfeng ChenMalaysian Palm Oil BoardYLYee Ying LeeMonash University Malaysia

Discussion

Loading...

Member takes

Implication

This research demonstrates enhanced delivery efficiency of diacylglycerol nanoparticles in the gastrointestinal tract, suggesting better drug administration strategies.

Key Points

  • The aim is to improve the delivery of bioactive peptides using diacylglycerol nanoparticles by optimizing surface characteristics.
  • Fabrication of diacylglycerol solid lipid nanoparticles with surface modifications using polydopamine and polyethylene glycol.
  • Evaluation of mucus penetration and intestinal epithelial transport through Caco-2/HT-29 cell models.
  • Comparison of modified nanoparticles with lipid controls like glyceryl tristearate and cetyl palmitate.
  • Surface modification with polydopamine and polyethylene glycol improved the permeability of DAG nanoparticles.
  • DAG particles showed better mucus penetration than glyceryl tristearate and cetyl palmitate SLNs.
  • DAG nanoparticles exhibited effective delivery of flaxseed cyclopeptide with enhanced anti-inflammatory effects.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/699e918df5123be5ed04f186https://doi.org/10.1021/acsami.5c23121
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polydopamine-Modified Liposomes: Preparation and Recent Applications in the Biomedical Field2024 · 23 citations
  2. 2Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery2021 · 399 citations
  3. 3Nanoparticle Hydrophobicity Dictates Immune Response2012 · 482 citations
  4. 4An Empirical IR Frequency Map for Ester C═O Stretching Vibrations2016 · 107 citations
  5. 5Molecular Design of Layer-by-Layer Functionalized Liposomes for Oral Drug Delivery2020 · 72 citations