What does this research mean for the field?

Bilberry extract alleviates gestational diabetes mellitus by coordinating TGR5/FXR signaling via a gut microbiota-bile acids axis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore if bilberry extract affects gestational diabetes by modulating specific signaling pathways through gut microbiota.

February 25, 2026Food & Function0 citations

Bilberry (Vaccinium myrtillus L.) Extract Alleviates Gestational Diabetes Mellitus by Coordinating TGR5/FXR Signaling via a Gut Microbiota-Bile Acids Axis

SJShunli JiangJining Medical University QSQiang SunNorth China Electric Power University CJChenyun JiangJining Medical University

Key Points

This research aims to explore if bilberry extract affects gestational diabetes by modulating specific signaling pathways through gut microbiota.
Investigated the role of bilberry extract in regulating gut microbiota.
Examined its impact on bile acids and TGR5/FXR signaling pathways.
Analyzed subsequent changes in GLP-1 levels in relation to gestational diabetes.
Bilberry extract significantly altered gut microbiota composition.
Enhanced bile acid levels were observed in treated subjects.
TGR5 and FXR signaling pathways were positively influenced, leading to increased GLP-1 secretion.

Abstract

Dietary anthocyanins are associated with a reduced risk of gestational diabetes mellitus (GDM). However, it remains unclear whether their efficacy is mediated through the gut microbiota-bile acids-TGR5/FXR-GLP-1 axis, a mechanism...

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