Why the study?
Does warfarin improve outcomes compared to aspirin in patients with heart failure, reduced LVEF, and sinus rhythm?
Population
Patients with heart failure, reduced LVEF, and sinus rhythm
Comparison
Warfarin vs Aspirin
Design
RCT
Authors
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Supports individualized therapy in HF with reduced LVEF and sinus rhythm; reinforces neutral net benefit of warfarin versus aspirin.
Does warfarin improve outcomes compared to aspirin in patients with heart failure, reduced LVEF, and sinus rhythm?
In patients with heart failure and sinus rhythm, the choice between warfarin and aspirin should be individualized, as warfarin's reduction in ischemic stroke is offset by an increased risk of major hemorrhage.
Homma et al. (2012) studied this question.
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