β-and Z-Selective Metal-Free Cyanation of Ynamides: A Direct Approach to Piperidines Fused to Arenes

Key Points

• To present a metal-free method for the β- and Z-selective hydrocyanation of ynamides.
• Utilized TMSCN and TBAF for the transformation.
• Employed TMSOTf to promote the reaction.
• Focused on regio- and stereoselectivity in terminal ynamides.
• Achieved exclusively Z-configured tertiary enamides.
• Demonstrated excellent regioselectivity in the transformation.