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February 26, 2026Blood AdvancesOpen Access

Long-term Health Outcomes in Older Blood or Marrow Transplantation Recipients: A Report from the BMTSS

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Authors

RBRusha BhandariCity of HopeQMQingrui MengUniversity of Alabama at BirminghamLHLindsey HagemanUniversity of Alabama at Birmingham

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Implication

Observational report shows increased frailty and poor health status in older BMT survivors, indicating substantial healthcare needs.

Key Points

  • This research aims to assess the long-term health outcomes of older blood or marrow transplantation recipients.
  • Included 1,581 survivors aged ≥60 who underwent BMT from 1990-2014
  • Identified health conditions using Common Terminology Criteria for Adverse Events
  • Compared health outcomes with 594 age-matched siblings using multivariable regression analysis
  • 72% prevalence of severe/life-threatening conditions in BMT survivors vs 51% in siblings (P<.001)
  • Higher odds of reporting poor health (OR 4.1) and functional impairment (OR=3.2) among survivors
  • Survivors showed a 5.3 overall SMR, with high infection-related mortality (SMR=35.2)
  • 3.8-fold increased risk of subsequent neoplasms, particularly Hodgkin lymphoma (SIR=18.5) and melanoma (SIR=7.4)

Cite This Study

Bhandari et al. (2026) studied this question.

synapsesocial.com/papers/699f956d1bc9fecf3dab3311https://doi.org/10.1182/bloodadvances.2025018477
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