Peripheral Metabolic–Redox Signaling as a Core Mechanism of Major Depressive Disorder: Evidence from Deep Metabolomic Phenotyping

Key Points

• This research explores how metabolic and redox signaling operates within major depressive disorder (MDD).
• Used deep metabolomic phenotyping to identify MDD metabotype.
• Analyzed metabolic networks associated with the pathogenesis of MDD.
• Evaluated potential drug targets related to various biochemical pathways.
• Identified a cohesive metabolic network linked to the NIMETOX pathogenesis of MDD.
• Highlighted lipoxygenase-15 and lipotoxicity as key factors in MDD.
• Proposed phospholipase A2 and lipid-redox intersections as potential drug targets.