Current diagnostic methods in endodontics, such as pulp sensibility tests, are subjective and lack precision in determining the true inflammatory and biological status of the dental pulp and periapical tissues. Proteomic and metabolomic approaches provide high-resolution, unbiased strategies for identifying objective biomarkers across multiple biological matrices relevant to endodontic diseases. This scoping review aims to systematically map the existing clinical and preclinical (animal and ex vivo) evidence on proteomic and metabolomic biomarkers associated with pulpitis and apical periodontitis. By synthesizing data across biological matrices, analytical platforms, and study designs, this review seeks to characterize the current landscape of Precision Endodontics, identify translational gaps between experimental and clinical research, and highlight areas requiring further validation. Given the heterogeneity of study designs, matrices, and analytical platforms, a scoping review methodology is the most appropriate approach to map the extent, nature, and gaps of the available evidence, and no quantitative synthesis is intended.
Brizuela et al. (Thu,) studied this question.