Characteristics of monogenic inflammatory bowel disease in very early-onset cases: a Japanese multicenter registry study

Natsuki Ito; T Kudo; Keisuke Jimbo; Ryusuke Nambu; Fumihiko Kakuta; Tatsuki Mizuochi; Takeshi Saito; S I Hagiwara; Naomi Iwata; Nao Tachibana; H Kumagai; T Ishige; Misaki Sugai; Mikihiro Inoue; Shigeo Nishimata; Hitoshi Tajiri; Eitaro Hiejima; Mika Sasaki; Sawako Kato; Hirotaka Shimizu; Yuri Hirano; Toshiaki Shimizu; Katsuhiro Arai; Japanese Pediatric Inflammatory Bowel Disease Registry (JPIBD-R)

doi:10.5217/ir.2025.00203

Key Points

This research aims to identify characteristics of very early-onset inflammatory bowel disease (VEO-IBD) linked to genetic factors.
Multicenter registry study conducted in Japan
Focused on patients presenting an IBD-U phenotype
Emphasized history of severe infections during infancy
Identified the need for prioritizing genetic analysis in specific VEO-IBD patients
Highlighted association with severe infections during early life

Abstract

Patients with VEO-IBD who present an IBD-U phenotype and have a history of severe infections during infancy should be prioritized for genetic analysis to investigate the possibility of monogenic IBD.

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Cite This Study

Ito et al. (2026) studied this question.

synapsesocial.com/papers/699f95841bc9fecf3dab3636 https://doi.org/10.5217/ir.2025.00203

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Characteristics of monogenic inflammatory bowel disease in very early-onset cases: a Japanese multicenter registry study

Key Points

Abstract

Discussion

Cite This Study

Characteristics of monogenic inflammatory bowel disease in very early-onset cases: a Japanese multicenter registry study

Key Points

Abstract

Discussion

Cite This Study

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