Impaired interhemispheric inhibition in isolated REM sleep Behavior Disorder: first exploratory Transcranial Magnetic Stimulation-based evidence

Giuseppe Lanza; Angelica Quercia; Elena Antelmi; R. Bella; Mariagiovanna Cantone; Patrizia Congiu; F. Cosentino; Franca Deriu; Michela Figorilli; A. Galeano; Angelo Garifoli; Francesca Ginatempo; B. Lanuzza; Claudio Liguori; Pietro Marano; Maria P. Mogavero; Manuela Morreale; A. Palmigiano; G. Pastorello; W. Paulus; Monica Puligheddu; Francesco Sarritzu; Giuseppe Toscano; Rossella Toscano; Mariangela Tripodi; Raffaele Ferri; Manuela Pennisi

doi:10.1093/sleep/zsag050

Key Points

This research investigates the role of GABAergic dysfunction in isolated REM sleep Behavior Disorder (iRBD).
Exploratory study using Transcranial Magnetic Stimulation (TMS)
Assessment of iSP duration and cSP latency
Involvement of transcallosal pathways
Prolonged iSP duration observed in iRBD participants
Alterations in cSP latency indicating potential GABAergic dysfunction
Findings contribute to understanding cognitive deficits and dream-enactment behaviors in iRBD.

Implication

Exploratory findings reveal GABAergic dysfunction in isolated REM sleep Behavior Disorder, suggesting insights for targeted interventions.

Abstract

Prolonged iSP duration and the finding on cSP latency in iRBD strengthen the notion of GABAergic dysfunction extending to transcallosal pathways. Such alterations might contribute to dream-enactment behaviors and subtle cognitive deficits observed. These exploratory findings open new avenues for understanding RBD pathophysiology and may support the development of targeted "pharmaco-TMS" strategies in prodromal synucleinopathies.

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Cite This Study

Lanza et al. (2026) studied this question.

synapsesocial.com/papers/699f95951bc9fecf3dab3778 https://doi.org/10.1093/sleep/zsag050

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Impaired interhemispheric inhibition in isolated REM sleep Behavior Disorder: first exploratory Transcranial Magnetic Stimulation-based evidence

Key Points

Implication

Abstract

Discussion

Cite This Study

Impaired interhemispheric inhibition in isolated REM sleep Behavior Disorder: first exploratory Transcranial Magnetic Stimulation-based evidence

Key Points

Implication

Abstract

Discussion

Cite This Study

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