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February 26, 2026Biomaterials Science1 citationsOpen Access

A thermosensitive hydrogel achieves sustained co-delivery of two therapeutic agents with distinct properties for preventing aseptic loosening

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YWYang WangWuhan Institute of TechnologyXWXin WangHohai UniversityHZHongjie ZhangDalian Institute of Chemical Physics

Key Points

  • This research aims to explore a thermosensitive hydrogel's ability to co-deliver two therapeutic agents for preventing aseptic loosening.
  • Developed a thermosensitive hydrogel for drug delivery.
  • Assessed co-delivery of therapeutic agents with distinct properties.
  • Evaluated impact on inflammation and bone resorption in relation to prosthesis stability.
  • The hydrogel successfully sustained co-delivery of agents.
  • Demonstrated reduced inflammation and bone resorption in vitro.
  • Improved the longevity of the prosthesis against aseptic loosening.

Abstract

Wear particle-induced prosthesis aseptic loosening severely affects the longevity of total joint arthroplasty. This condition arises from periprosthetic osteolysis, which is driven by excessive inflammation and enhanced bone resorption under...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/699f95951bc9fecf3dab3853https://doi.org/10.1039/d6bm00096g
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