Aim: To investigate the effect of coingestion of fructose with fat cream on postprandial lipid metabolism in Japanese female university students, using remnant and non-remnant indices. Methods: Healthy young Japanese women (n=54) with apolipoprotein E phenotype 3/3 were enrolled. They participated on two occasions, ingesting either fat cream (OFTT creamsupTM/sup, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat) alone or fat cream with fructose (0.5 g/kg). Venous blood samples were collected before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: After ingestion of fat cream alone, serum concentration of triglyceride increased at 2 and 4 h, but non-remnant triglyceride concentration did not rise during the experiment. In contrast, after ingesting fructose in combination with fat cream, both serum triglyceride and non-remnant triglyceride levels increased at 4 h and did not return to baseline by the end of the experiment. The ratio of remnant triglyceride to total triglyceride, and an index of particle size were higher in the fructose with fat cream than fat cream alone at 4 h after ingestion. Conclusion: Coingestion of fructose with fat cream, but not fat cream alone, exacerbated postprandial lipidemia primarily by stimulating endogenous non-remnant triglyceride secretion.
Mizutani-Watanabe et al. (Fri,) studied this question.