What question did this study set out to answer?

This research aims to elucidate the role of APOO in macrophage polarization and its molecular mechanisms in breast cancer.

Breast Tumor-Secreted APOO Promotes Macrophage Polarization Towards the M2 Phenotype via ADCK2

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Gene expression analysis reveals APOO enhances macrophage polarization in breast cancer, suggesting it as a biomarker and therapy target.

This research aims to elucidate the role of APOO in macrophage polarization and its molecular mechanisms in breast cancer.
Analyzed gene expression data from single-cell RNA sequencing and TCGA-BRCA.
Overexpressed APOO in tumor cells and co-cultured with macrophages.
Assessed M2 polarization through CD206 flow cytometry and qRT-PCR.
Identified APOO as a key differentially expressed gene in breast cancer.
Higher APOO expression was correlated with increased M2-like macrophage infiltration.
Functional assays indicated APOO promotes M2 polarization through the ADCK2 signaling pathway.

Wang et al. (2026) studied this question.

View Full Paper

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View Full Paper

Ask AI

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Authors

Gene expression analysis reveals APOO enhances macrophage polarization in breast cancer, suggesting it as a biomarker and therapy target.

This research aims to elucidate the role of APOO in macrophage polarization and its molecular mechanisms in breast cancer.
Analyzed gene expression data from single-cell RNA sequencing and TCGA-BRCA.
Overexpressed APOO in tumor cells and co-cultured with macrophages.
Assessed M2 polarization through CD206 flow cytometry and qRT-PCR.
Identified APOO as a key differentially expressed gene in breast cancer.
Higher APOO expression was correlated with increased M2-like macrophage infiltration.
Functional assays indicated APOO promotes M2 polarization through the ADCK2 signaling pathway.

Wang et al. (2026) studied this question.

View Full Paper

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Bookmark