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This is a In Vitro Study study.

APOA1 as a Potential Therapeutic Target and Novel Biomarker in Lung Adenocarcinoma

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Integrated analysis reveals APOA1's role as a tumor suppressor and potential biomarker in lung adenocarcinoma, indicating new therapeutic strategies.

APOA1 acts as a tumor suppressor in lung adenocarcinoma, reducing tumor growth and progression.
APOA1 overexpression led to significant reductions in invasion and tumor volume, with AUC of 0.942 indicating high diagnostic performance.
Assessment using multi-omics approaches and patient-serum validation highlighted the role of APOA1 in drug-response and epigenetics.
Findings support that targeting APOA1 may enable improved therapeutic stratification and immunomodulatory strategies in lung adenocarcinoma.

Sun et al. (2025) studied this question.

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Integrated analysis reveals APOA1's role as a tumor suppressor and potential biomarker in lung adenocarcinoma, indicating new therapeutic strategies.