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August 16, 2025Open Access

APOA1 as a Potential Therapeutic Target and Novel Biomarker in Lung Adenocarcinoma

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Authors

YSYan SunJSJie ShenYLYing Lin

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Overview

Observational analysis shows APOA1 correlates with poor survival in lung adenocarcinoma, suggesting it may serve as a prognostic biomarker.

Key Points

  • APOA1 downregulation correlates with poor overall survival in lung adenocarcinoma, highlighting its prognostic potential.
  • Study found that APOA1 expression levels had an AUC of 0.942 for diagnostic accuracy in distinguishing LUAD from healthy controls.
  • Multi-omics analysis using multiple databases identified APOA1 as a key player in tumorigenesis and immune modulation.
  • Enhanced drug sensitivity was observed with agents like selumetinib in high-APOA1 contexts, indicating therapeutic implications.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68a366a80a429f797332c8echttps://doi.org/10.22541/au.175472291.15215916/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1APOA1 as a Potential Therapeutic Target and Novel Biomarker in Lung Adenocarcinoma2025
  2. 2Pan-cancer analysis identifies APOC1 as a TAM-derived modulator of adaptive immune resistance and predictor of therapeutic response2026
  3. 3APOA1 mRNA and serum APOA1 protein as diagnostic and prognostic biomarkers in gastric cancer2024 · 10 citations
  4. 4Integrated Bioinformatics Analysis and Cellular Experimental Validation Identify Lipoprotein Lipase Gene as a Novel Biomarker for Tumorigenesis and Prognosis in Lung Adenocarcinoma2025 · 1 citations
  5. 5Overexpression of ANAPC1 Affects the Cell Cycle Pathway to Promote theProgression of Lung Adenocarcinoma2026