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PGK1 Drives Cardiac Hypertrophy by Regulating the Vimentin/PI3K/Akt Pathway | Synapse

February 26, 2026Circulation Research0 citations

PGK1 Drives Cardiac Hypertrophy by Regulating the Vimentin/PI3K/Akt Pathway

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XZXue-Xue ZhuJiangnan University AZAo-Yuan ZhangJiangnan University GXGui-Wen XuJiangnan University

Key Points

This research investigates the role of PGK1 in cardiac hypertrophy and its regulatory mechanisms.
Examined the function of PGK1 in myocardial hypertrophy
Analyzed downstream signaling pathways including vimentin, PI3K, and Akt
PGK1 is critical for myocardial hypertrophy development
Activation of the vimentin/PI3K/Akt/ferroptosis pathway occurs downstream of PGK1

Abstract

Our findings highlight a critical role for PGK1 in myocardial hypertrophy, with downstream activation of the vimentin/PI3K/Akt/ferroptosis pathway.

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Cite This Study

Zhu et al. (Tue,) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3ea7 https://doi.org/https://doi.org/10.1161/circresaha.125.327173

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