A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching

Lixuan Lin; Kaiyi Liang; Xiuli Gao; Jiang Li; Linjie Guo; Kai Jiao; Lihua Wang

doi:10.1039/d5na01166c

January 1, 2026Nanoscale AdvancesOpen Access

A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching

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Key Points

This research aims to address the stability and functionality of dynamic DNA nanomachines under varying physiological pH.
Systematic evaluation of a six-helix DNA nanomachine
Investigation of performance across different pH levels
Identified that physiological pH significantly affects stability
Demonstrated conformation changes enhance functional performance of the DNA nanomachine

Implication

Evaluation of stability and function in a pH-Stable DNA nanomachine suggests improved performance under physiological conditions.

Abstract

The heterogeneity of physiological pH poses a major challenge to the stability and function of dynamic DNA nanomachines. Here, we systematically evaluate the performance of a six-helix DNA nanomachine (6H-NNM)...

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3edd https://doi.org/10.1039/d5na01166c

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A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching

Key Points

Implication

Abstract

Discussion

Cite This Study

A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching

Key Points

Implication

Abstract

Discussion

Cite This Study

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