What question did this study set out to answer?

This research aims to explore the role of PKMζ in the prefrontal cortex related to cocaine behaviors.

February 26, 2026PsychopharmacologyOpen Access

PKMζ in the prefrontal cortex alters cocaine cue-induced reinstatement in a sex-specific manner

View Full Paper

Ask AI

Bookmark

This research aims to explore the role of PKMζ in the prefrontal cortex related to cocaine behaviors.
Used inducible genetic deletion model to knockdown PKMζ in prefrontal cortex of male and female mice.
Assessed cocaine taking and seeking behaviors using fixed-ratio and progressive ratio schedules.
No effect of PKMζ knockout on cocaine taking during fixed-ratio self-administration in both sexes.
Female mice with PKMζ knockout exhibit blunted cue-induced cocaine seeking compared to males.

No takes yet. Share an insight, caveat, or question.

Inducible deletion of PKMζ reduces cue-induced cocaine seeking in female mice, suggesting sex differences in IGF-1 signaling.

Kniffin et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark