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Coexisting pulmonary tuberculosis in non-small cell lung cancer patients is associated with worse overall survival outcomes compared to those with non-small cell lung cancer alone. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

February 26, 2026Journal of Inflammation ResearchOpen Access

Clinical Characteristics and Prognosis of Non-Small Cell Lung Cancer with Coexisting Pulmonary Tuberculosis: A Retrospective Matched-Cohort Study

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Authors

JZJing ZhengHangzhou Red Cross Hospital HXHaoran XieAffiliated Hospital of Hangzhou Normal University GYGuocan YuHangzhou Red Cross Hospital

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Implication

A matched-cohort study reveals worse survival outcomes in non-small cell lung cancer patients with pulmonary tuberculosis, indicating a need for integrated management.

Key Points

This study investigates the clinical characteristics and prognosis of non-small cell lung cancer patients with coexisting pulmonary tuberculosis.
Retrospective matched cohort study design
Involved 132 patients (66 PTB-NSCLC cases and 66 NSCLC-only controls)
Matched based on age and TNM stage
Used Kaplan–Meier analysis for survival evaluation
Conducted hazard ratio analysis via Cox proportional hazards regression.
PTB-NSCLC cases constituted about 4.7% of all NSCLC patients diagnosed between 2017-2023
PTB-NSCLC patients had higher erythrocyte sedimentation rates and lower serum albumin levels
Significant worse overall survival for PTB-NSCLC patients (median OS: 32 vs 72 months)
High modified Glasgow Prognostic Score was an independent predictor of poor outcomes
Surgical intervention was associated with improved survival.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/699fe2eb95ddcd3a253e657f https://doi.org/10.2147/jir.s586621

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Implication

A matched-cohort study reveals worse survival outcomes in non-small cell lung cancer patients with pulmonary tuberculosis, indicating a need for integrated management.

Clinical Characteristics and Prognosis of Non-Small Cell Lung Cancer with Coexisting Pulmonary Tuberculosis: A Retrospective Matched-Cohort Study

Discussion

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Key Points

Cite This Study

Clinical Characteristics and Prognosis of Non-Small Cell Lung Cancer with Coexisting Pulmonary Tuberculosis: A Retrospective Matched-Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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