Safety and efficacy of long-term filgotinib treatment in Japanese patients with ulcerative colitis: an interim subgroup analysis of the SELECTION long-term extension study.

Katsuyoshi Matsuoka; Erina Hata; Toshihiko Kaise; Christine Rudolph; Toshifumi Hibi

doi:10.1093/crocol/otag006

January 1, 2026

Safety and efficacy of long-term filgotinib treatment in Japanese patients with ulcerative colitis: an interim subgroup analysis of the SELECTION long-term extension study.

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Key Points

To assess the long-term safety and efficacy of filgotinib in Japanese patients with ulcerative colitis.
Conducted an interim subgroup analysis of the SELECTION long-term extension study.
Evaluated patient outcomes over a treatment period of up to 3 years.
Monitored incidence of infections and herpes zoster among participants.
Filgotinib maintained and improved symptomatic remission for up to 3 years.
Health-related quality of life showed significant improvement.
Japanese patients had a higher incidence of infections and herpes zoster compared to the overall population.

Implication

Interim analysis shows improved remission in ulcerative colitis, suggesting filgotinib’s benefit in Japanese patients.

Abstract

Filgotinib demonstrated an acceptable long-term benefit-risk profile in Japanese patients, maintaining and improving symptomatic and HRQoL remission for up to 3 years. Japanese patients had a numerically higher incidence of infections and herpes zoster than the overall SELECTIONLTE population.

Discussion

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Cite This Study

Matsuoka et al. (2026) studied this question.

synapsesocial.com/papers/699fe32295ddcd3a253e6c9f https://doi.org/10.1093/crocol/otag006

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Safety and efficacy of long-term filgotinib treatment in Japanese patients with ulcerative colitis: an interim subgroup analysis of the SELECTION long-term extension study.

Key Points

Implication

Abstract

Discussion

Cite This Study

Safety and efficacy of long-term filgotinib treatment in Japanese patients with ulcerative colitis: an interim subgroup analysis of the SELECTION long-term extension study.

Key Points

Implication

Abstract

Discussion

Cite This Study

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