What does this research mean for the field?

Focused transcranial ultrasound stimulation (TUS) can induce paradoxical negative BOLD signals in activated cortical regions of murine brains, despite increased total hemoglobin levels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This research aims to understand the physiological mechanisms of BOLD responses during transcranial ultrasound stimulation.

February 26, 2026Open Access

Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging

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Authors

YCYi ChenHunan University of Traditional Chinese Medicine ZCZhenyue Chen HEHéctor EstradaUniversity of Zurich

Discussion

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Implication

Demonstrates paradoxical BOLD responses in murine brains during ultrasound stimulation, indicating complex hemodynamic interactions.

Key Points

This research aims to understand the physiological mechanisms of BOLD responses during transcranial ultrasound stimulation.
Developed a hybrid optoacoustic and magnetic resonance imaging system (OMRITUS)
Monitored TUS responses in murine brains
Characterized hemodynamic changes using total hemoglobin measurements
Examined multispectral optoacoustic readings for hemoglobin types
Observed paradoxical negative BOLD signals in activated cortical regions
Noted increased total hemoglobin levels during stimulation
Found a stronger increase in deoxygenated hemoglobin compared to oxygenated hemoglobin

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/699fe33695ddcd3a253e6d5f https://doi.org/10.5167/uzh-292392

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