Abstract: Wounds cause anatomical and physical disruption to healthy skin after an injury and are a major global health concern. Wound healing is a multifaceted and dynamic process that entails a series of molecular and cellular interactions, encompassing four primary stages: hemostasis, inflammation, proliferation, and remodeling. Impaired wound healing, being a significant health concern worldwide, is exacerbated by microbial infections, oxidative stress, and chronic diseases. Traditional herbal systems have been used for ages due to their anti-inflammatory, antibacterial, and antioxidant properties, but their application is limited by poor stability, bioavailability, and inconsistent therapeutic outcomes. To overcome these limitations, this work emphasizes the potential of nanotechnology in integrating herbal treatments into advanced wound care systems. Nanomaterials, such as hydrogels, lipid-based carriers, nanocomposites, and nanoparticles, can enhance the efficacy, stability, and targeted delivery of herbal bioactive compounds to increase therapeutic outcomes. The study also demonstrates the use of these nanomaterials in accelerating wound closure, encouraging angiogenesis, and reducing scarring. The review also highlights how natural antioxidants reduce oxidative stress and promote tissue regeneration, and it clarifies the role of reactive oxygen species in wound healing. By integrating traditional medicinal knowledge with modern nanotechnology, this manuscript envisions a transformative approach to wound care. The findings highlight the need for continued innovation in biomaterials and nanotechnology to develop scalable, effective, and sustainable solutions for wound management, addressing both acute and chronic conditions.
Kumari et al. (Thu,) studied this question.
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