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February 23, 2026

The influence of age and the presence of prostate cancer on prostate volume, PSA and PSA density.

Jill Rusbridge Iztok Caglic Liness Thavaraja Nikita Sushentsev Tristan Barrett

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Key Points

The research aims to analyze the relationship between age, prostate cancer presence, and various prostate measures.
Non-linear assessment of prostate volume changes with age in asymptomatic men.
Evaluation of PSA levels across different age groups.
Determination of a constant PSA-D threshold across ages.
Prostate volume changes non-linearly with age.
Age-related PSA thresholds may be necessary.
A PSA-D threshold of 0.15 ng/mL² is applicable across all ages.

Implication

Analysis examines prostate volume and PSA changes in asymptomatic men, suggesting age-related thresholds for PSA levels.

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Cite This Study

Rusbridge et al. (2026) studied this question.

synapsesocial.com/papers/699fe34695ddcd3a253e6f46 https://doi.org/10.1111/bju.70169

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The influence of age and the presence of prostate cancer on prostate volume, PSA and PSA densityOriginal Research · 2026
2The influence of age and the presence of prostate cancer on prostate volume, PSA and PSA-DCohort Study · 2026
3Assessment and Modeling of the Relationship Between Age, Prostate Volume, and Prostate‐Specific Antigen in a Population of Men From Sub‐Saharan Africa With a Low Risk of Prostate CancerOriginal Research · 2026
4Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1Retrospective Study · 2013 · 24 citations
5PSA density for clinically significant prostate cancer detection: a retrospective cohort study on the influence of age and prostate volumeRetrospective Study · 2026 · 1 citations