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February 26, 2026ACS Nano

Bioinspired Multilayered Conductive Nerve Guidance Conduit Built on Hydrogels and Knitted Silk Fiber Sleeves for Peripheral Nerve Regeneration

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Authors

ZZZhanchi ZhuSGS. X. GaoZSZhaoming Song

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Overview

Composite nerve conduit promotes nerve regeneration, suggesting potential for overcoming peripheral nerve injury challenges.

Key Points

  • The aim is to develop a bioinspired nerve conduit that replicates the structure and function of natural nerves for effective regeneration.
  • Created a multilayered conduit using silk fibroin, gelatin methacrylate, and polypyrrole.
  • Integrated an outer knitted silk sleeve for support and an inner hydrogel for cellular functions.
  • Conducted in vitro and in vivo testing to evaluate biocompatibility and nerve regeneration.
  • The conduit demonstrated significant nerve regeneration in the sciatic nerve of rats.
  • Achieved functional recovery post-transplantation.
  • Exhibited properties like mechanical stability, electrical conductivity, and biocompatibility.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/699fe34695ddcd3a253e6fe5https://doi.org/10.1021/acsnano.5c18775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conductive silk fibroin-based hydrogel composite conduit with anti-inflammatory and anti-scarring properties for peripheral nerve regeneration2026
  2. 2A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties2024 · 5 citations
  3. 3Electrospun silk fibroin/polylactic acid conduit filled with proangiogenic carboxylated silk fibroin/chitosan hydrogel facilitates peripheral nerve regeneration2024 · 9 citations
  4. 4Biomimetic multi-channel nerve conduits with micro/nanostructures for rapid nerve repair2024 · 36 citations
  5. 5Constructing Nerve Guidance Conduit using dECM‐Doped Conductive Hydrogel to Promote Peripheral Nerve Regeneration2024 · 21 citations