What does this research mean for the field?

Genistein ameliorates renal fibrosis in chronic kidney disease by targeting the CCAR2/SIRT1/p53 signaling axis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to explore the role of genistein in renal fibrosis associated with chronic kidney disease and its underlying mechanisms.

February 26, 2026PhytomedicineOpen Access

Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis

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The aim was to explore the role of genistein in renal fibrosis associated with chronic kidney disease and its underlying mechanisms.
Utilized UUO and adenine-induced murine CKD models to assess fibrosis
Conducted pull-down assays with biotin-conjugated genistein to identify target proteins
Performed mass spectrometry analysis to confirm CCAR2 as a target
Validated interactions using CETSA, molecular docking, and Co-IP
Investigated the effects of CCAR2 knockdown and genistein treatment on fibrosis
Genistein significantly reduced renal fibrosis in murine models
Identified CCAR2 as a direct target of genistein
Inhibition of CCAR2 restored SIRT1 activity, decreasing p53 acetylation
CCAR2 overexpression led to increased fibrogenesis, while its knockdown alleviated fibrosis
Findings suggest a potential therapeutic approach targeting the CCAR2/SIRT1/p53 signaling axis

Discussion

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Implication

Demonstrates that genistein reduces renal fibrosis in chronic kidney disease, indicating potential therapeutic benefits.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/699fe37b95ddcd3a253e7537 https://doi.org/10.1016/j.phymed.2026.157998

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Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis

Key Points

Discussion

Implication

Cite This Study

Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis

Key Points

Discussion

Implication

Cite This Study

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