Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway. | Synapse
Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.
The study aims to explore how acupuncture affects the progression of lumbar disc herniation by influencing specific cellular pathways.
Investigated the SIRT1/Sestrin2 autophagy pathway's role in lumbar disc herniation.
Applied acupuncture as an intervention to assess its effects on nucleus pulposus cells.
Analyzed autophagy levels in response to treatment.
Acupuncture effectively activated the SIRT1/Sestrin2 pathway.
Significant reduction in the progression of lumbar disc herniation was observed.
Regulation of autophagy levels in nucleus pulposus cells linked to treatment efficacy.
Abstract
AC relieves the development of LDH by activating the SIRT1/Sestrin2 autophagy pathway. Our study provides a new molecular mechanism for the AC treatment of LDH.