Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

Rong Zhao; Jia Lu; Pengyue Zhang; Yiming Zhang; Chang Li; Tao Zhang; Xi Chen; Hangqi Zheng; Jie Yang; Ming Jing

doi:10.14670/hh-25-050

February 24, 2026

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

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Key Points

The study aims to explore how acupuncture affects the progression of lumbar disc herniation by influencing specific cellular pathways.
Investigated the SIRT1/Sestrin2 autophagy pathway's role in lumbar disc herniation.
Applied acupuncture as an intervention to assess its effects on nucleus pulposus cells.
Analyzed autophagy levels in response to treatment.
Acupuncture effectively activated the SIRT1/Sestrin2 pathway.
Significant reduction in the progression of lumbar disc herniation was observed.
Regulation of autophagy levels in nucleus pulposus cells linked to treatment efficacy.

Implication

Acupuncture alleviates lumbar disc herniation progression, indicating a novel molecular mechanism for treatment.

Abstract

AC relieves the development of LDH by activating the SIRT1/Sestrin2 autophagy pathway. Our study provides a new molecular mechanism for the AC treatment of LDH.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/699fe39d95ddcd3a253e7a1e https://doi.org/10.14670/hh-25-050

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Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

Key Points

Implication

Abstract

Discussion

Cite This Study

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

Key Points

Implication

Abstract

Discussion

Cite This Study

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