What question did this study set out to answer?

To evaluate the regenerative potential of dental stem cell-derived exosomes (DSC-Exos) and factors influencing their efficacy.

February 26, 2026Molecular Biology ReportsOpen Access

Efficacy of dental stem cell–derived exosomes for pulp regeneration: a systematic review of clinical, animal, and in vitro studies

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Systematic review shows DSC-derived exosomes promote pulp regeneration in diverse studies, indicating promising cell-free therapies.

To evaluate the regenerative potential of dental stem cell-derived exosomes (DSC-Exos) and factors influencing their efficacy.
Conducted a systematic review of studies from PubMed, Scopus, Web of Science, and Embase
Assessed risk of bias using RoB 2.0, SYRCLE, and QUIN tools
Included clinical, animal, and in vitro studies focusing on DSC-Exos
DSC-Exos promoted cell proliferation and migration and upregulated odontogenic and angiogenic markers
Animal models showed significant formation of vascularized pulp-like tissue and organized tubular dentin
A 24-month clinical pilot confirmed restored pulp sensitivity without safety concerns

Godoi-Lopes et al. (2026) studied this question.

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