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This study aims to explore surgical options for large periapical lesions that do not respond to conventional endodontic therapy.

Surgical management of large periapical lesion- A case series

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This study aims to explore surgical options for large periapical lesions that do not respond to conventional endodontic therapy.
Presented two case reports of patients with large periapical lesions after failed root canal treatment.
Performed periradicular surgery including apicoectomy and cyst enucleation.
Used mineral trioxide aggregate (MTA) for obturation and platelet-rich fibrin (PRF) to aid healing.
Follow-up included CBCT imaging to assess bone regeneration.
Both patients showed satisfactory resolution of symptoms after surgery.
CBCT revealed significant bone regeneration in the areas impacted by the lesions.
Use of PRF and MTA contributed positively to clinical outcomes and biological healing.

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Case series demonstrates effective surgical treatment of large periapical lesions, suggesting improved outcomes with regenerative materials.

Virk et al. (2025) studied this question.

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Case series demonstrates effective surgical treatment of large periapical lesions, suggesting improved outcomes with regenerative materials.