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Phase-Specific Changes in Vital Signs and Electrocardiogram Findings During Hyperbaric Oxygen Therapy in Hemodynamically Stable Patients: A Prospective Observational Study

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Observational study evaluates physiological responses during hyperbaric oxygen therapy in non-emergent patients, suggesting predictable changes.

This study aims to characterize physiological changes during hyperbaric oxygen therapy in hemodynamically stable patients across various treatment phases.
Enrolled 50 hemodynamically stable non-emergent patients undergoing hyperbaric oxygen therapy.
Recorded vital signs and ECG findings across pre-compression, compression, maintenance, decompression, and post-treatment phases.
Analyzed data using linear mixed models for vital signs and generalized linear mixed models for ECG abnormalities.
Heart rate decreased significantly across all HBOT phases compared with baseline.
Blood pressure remained stable during compression and maintenance but increased significantly during decompression and post-treatment.
Transient ECG abnormalities were observed in 10.0% of patients, mainly during compression and maintenance.
Oxygen saturation remained within normal ranges throughout all phases.
No significant oxygen toxicity or serious adverse events were observed.

Kim et al. (2026) studied this question.

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Observational study evaluates physiological responses during hyperbaric oxygen therapy in non-emergent patients, suggesting predictable changes.