What question did this study set out to answer?

This research aims to evaluate the predictive significance of CCTA-FFR, TyG index, and NLR in coronary atherosclerosis stenosis assessment.

February 26, 2026Journal of Investigative Medicine

EXPRESS: Investigation into the Significance of CCTA-FFR, TyG Index, and NLR in Assessing the Stenosis Degree of Coronary Atherosclerosis

Q: What are the key findings of this study?

CCTA-FFR, TyG index, and NLR effectively differentiate moderate-to-severe coronary stenosis with M-SS patients showing higher TyG (9.49 vs 8.61) and NLR (3.12 vs 2.69) and lower CCTA-FFR.

View Full Paper

Ask AI

Bookmark

Key result

Lower CCTA-FFR, higher TyG index, and elevated NLR effectively differentiate moderate-to-severe coronary stenosis.

Why the study?

The study aimed to investigate the predictive significance of CCTA-FFR, lipid profiles, the TyG index, and NLR in assessing the degree of coronary atherosclerosis stenosis.

Do CCTA-FFR, TyG index, and NLR correlate with the degree of coronary atherosclerosis stenosis in elderly patients with CHD?

Population

80 patients with CHD aged ≥55 years who underwent CCTA

Comparison

Mild stenosis vs moderate-to-severe stenosis by Gensini score

Design

Retrospective study

Authors

DPDabin PanWannan Medical College JPJianyuan PanUniversity of Science and Technology of China LZLintao ZhaWannan Medical College

Discussion

Member takes

Implication

May aid non-invasive risk stratification in elderly CHD; leaves open clinical utility pending larger prospective validation.

Key Points

This research aims to evaluate the predictive significance of CCTA-FFR, TyG index, and NLR in coronary atherosclerosis stenosis assessment.
Retrospective analysis of data from 80 CHD patients aged ≥55 years
Participants stratified into mild stenosis and moderate-to-severe stenosis groups using the Gensini scoring system
Comparison of baseline characteristics, CCTA-derived parameters, metabolic markers, and inflammatory indicators
M-SS group had significantly higher Gensini scores (28.65 vs. 21.34, p<0.001) and CAC scores (25.14 vs. 22.73, p<0.01)
TyG index and NLR were higher in M-SS group compared to MS group (9.49 vs. 8.61, p<0.001; 3.12 vs. 2.69, p<0.02)
CCTA-FFR value was higher in the MS group than in the M-SS group
Inverse correlations between CCTA-FFR with Gensini and CAC scores; positive correlations of NLR and TyG index with Gensini and CAC scores

Structured PICO

Do CCTA-FFR, TyG index, and NLR correlate with the degree of coronary atherosclerosis stenosis in elderly patients with CHD?

Population

80 patients with coronary heart disease (CHD) aged ≥55 years who underwent coronary computed tomography angiography (CCTA)

Intervention

Assessment of CCTA-derived fractional flow reserve (CCTA-FFR), triglyceride glucose (TyG) index, and neutrophil-to-lymphocyte ratio (NLR)

Comparator

Mild stenosis (MS) versus moderate-to-severe stenosis (M-SS) based on the Gensini scoring system

Outcome

Degree of coronary atherosclerosis stenosis (assessed via Gensini scores and coronary artery calcium [CAC] scores)surrogate

The integration of CCTA-FFR, TyG index, and NLR provides a comprehensive non-invasive tool to assess coronary stenosis severity and aid in risk stratification for elderly patients with CHD.

Cite This Study

Pan et al. (2026) studied this question. CCTA-FFR, TyG index, and NLR effectively differentiate moderate-to-severe coronary stenosis with M-SS patients showing higher TyG (9.49 vs 8.61) and NLR (3.12 vs 2.69) and lower CCTA-FFR.

synapsesocial.com/papers/699fe3ec95ddcd3a253e805d https://doi.org/10.1177/10815589261429533

Topics

Coronary CT angiography

View Full Paper

Ask AI

Bookmark

EXPRESS: Investigation into the Significance of CCTA-FFR, TyG Index, and NLR in Assessing the Stenosis Degree of Coronary Atherosclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

EXPRESS: Investigation into the Significance of CCTA-FFR, TyG Index, and NLR in Assessing the Stenosis Degree of Coronary Atherosclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider