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February 26, 2026Journal of Materials Chemistry B0 citations

Poly(γ-glutamic acid)-thickened PLLA microspheres with enhanced biocompatibility and efficacy in aged mice

DRDan-Qi RenHPHui PengYZYue Zhang

Key Points

  • To investigate the biocompatibility and effectiveness of γ-PGA thickened PLLA microspheres for skin rejuvenation in aged mice.
  • Utilized γ-PGA to enhance PLLA microspheres
  • Evaluated microsphere deposition stability
  • Assessed collagen regeneration properties
  • Conducted safety assessments over time in aged mice
  • Demonstrated enhanced biocompatibility of microspheres
  • Showed significant collagen regeneration in aged skin
  • Confirmed long-term safety and efficacy in the tested population

Abstract

This study presents γ-PGA thickened PLLA microspheres for skin rejuvenation. The formulation ensures stable deposition and enhances biocompatibility, stimulating sustainable collagen regeneration and long-term safety in aged skin.

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Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/699fe3f995ddcd3a253e81f1https://doi.org/10.1039/d5tb02761f
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