Clinical utility of estimated glucose disposal rate as a surrogate marker of insulin resistance in patients with type 2 diabetes mellitus

Objectives To calculate estimated glucose disposal rate (eGDR) in newly diagnosed treatment naive patients with type 2 diabetes mellitus (T2DM) and correlate it with homeostatic model assessment of insulin resistance (HOMA-IR) and clinical/ biochemical parameters. Material and Methods eGDR was calculated using a formula based on waist circumference (WC) and body mass index (BMI) in 60 patients newly diagnosed with T2DM. HOMA-IR was calculated using fasting values of plasma glucose and insulin. Serum fasting insulin and serum total antioxidant status (TAS) were estimated using commercially available kits. Results Mean age of the participants was 48+/-10.1 years (range:29-60 years). HOMA1-IR values were in the range of 1.2-34.4 while eGDR values were in the range of 4.9-12.5 mg/Kg/min. A significant negative association between HOMA1-IR and eGDR/eGDR BMI was noted. Conclusion The use of eGDR as a surrogate marker instead of HOMA-IR needs to be validated, and necessary modifications should be made before its application in patients with T2DM.