The rise and rise of vascular dysfunction in Alzheimer’s disease

Q: What does this research mean for the field?

Vascular dysfunction is increasingly recognized as a significant factor in the pathogenesis of Alzheimer's disease. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Raj N Kalaria

doi:10.1093/brain/awag076

February 24, 2026Brain

The rise and rise of vascular dysfunction in Alzheimer’s disease

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Key Points

This commentary discusses the implications of vascular dysfunction in the pathogenesis of Alzheimer's disease, focusing on recent findings.
Analysis of post-mortem evidence regarding vascular changes in Alzheimer's disease
Review of existing literature on angiogenesis and dementia
Exploration of neurovascular coupling dynamics in early stages of the disease.
Identified evidence of abnormal angiogenesis in early Alzheimer's disease models.
Highlighted significant impairment in blood-brain barrier function.
Discussed implications of disturbed cerebral blood flow for neurodegeneration.

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Implication

This commentary highlights abnormal vascular function in Alzheimer's disease, indicating its significance in disease progression.

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Cite This Study

Raj N Kalaria (2026) studied this question.

synapsesocial.com/papers/699fe41d95ddcd3a253e85ad https://doi.org/10.1093/brain/awag076

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The rise and rise of vascular dysfunction in Alzheimer’s disease

Key Points

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Implication

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Cite This Study

The rise and rise of vascular dysfunction in Alzheimer’s disease

Key Points

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Implication

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Cite This Study

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