The rise and rise of vascular dysfunction in Alzheimer’s disease | Synapse
February 26, 2026
The rise and rise of vascular dysfunction in Alzheimer’s disease
Key Points
This commentary discusses the implications of vascular dysfunction in the pathogenesis of Alzheimer's disease, focusing on recent findings.
Analysis of post-mortem evidence regarding vascular changes in Alzheimer's disease
Review of existing literature on angiogenesis and dementia
Exploration of neurovascular coupling dynamics in early stages of the disease.
Identified evidence of abnormal angiogenesis in early Alzheimer's disease models.
Highlighted significant impairment in blood-brain barrier function.
Discussed implications of disturbed cerebral blood flow for neurodegeneration.
Abstract
This scientific commentary refers to ‘Post-mortem evidence of pathogenic angiogenesis and abnormal vascular function in early Alzheimer's disease’ by Asby et al. (https://doi.org/10.1093/brain/awaf394).