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February 26, 2026BMC Neurology0 citationsOpen Access

Monocyte-to-High-Density Lipoprotein Cholesterol Ratio Predicts Hematoma Expansion in ICH

Monocyte-to-high-density lipoprotein cholesterol ratio predicts hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

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Authors

YXYilin XuYCYifei ChuLPLilei Peng

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Overview

Investigation shows monocyte-to-high-density lipoprotein cholesterol ratio predicts poor outcomes in ICH, suggesting its prognostic importance.

Key Points

  • The study aims to evaluate the predictive capacity of the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) for outcomes in spontaneous intracerebral hemorrhage (ICH) patients.
  • Clinical, imaging, and laboratory data collected from ICH patients
  • Used multivariable logistic regression models to analyze MHR and outcomes
  • Determined optimal cutoff of MHR using receiver operating characteristic (ROC) curve analysis
  • Included 541 adult patients with spontaneous ICH
  • Higher MHR at admission was an independent predictor of hematoma expansion (p = 0.047)
  • Optimal MHR cutoff for predicting hematoma expansion was determined to be 0.275
  • MHR ≥ 0.275 was associated with poor one-year prognosis in ICH patients (p = 0.033)
  • MHR strongly correlated with risks of hematoma expansion and unfavorable prognosis

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/699fe41d95ddcd3a253e8619https://doi.org/10.1186/s12883-026-04744-5
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